
Polysubstance Detox & Treatment in the Los Angeles Area
- Physician-managed multi-substance detox
- One coordinated plan, one home
- Owned & run by two physicians
- In-house psychiatry & medical care
Prefer to talk? Call 24/7: (818) 264-4388
What is polysubstance use?
Polysubstance use means using more than one drug, either at the same time or over the same period, such as combining alcohol with benzodiazepines, or opioids with stimulants ("speedballs"). Often it's intentional (to enhance or balance effects), but increasingly it's unintentional, as illicit drugs are frequently contaminated with fentanyl (NIDA/CDC). Polysubstance use is common, and it makes both overdose and withdrawal substantially more complicated and dangerous.
In fact, polysubstance use is increasingly the norm rather than the exception in addiction, and the fentanyl crisis has made it far more dangerous, because even people who intend to use only one drug may unknowingly be exposed to others. Because each substance affects the brain and body differently, the combined toll is hard to predict.
One common, deadly example: a stimulant can mask how sedated a person actually is from a depressant, leading them to take more and stop breathing. Untangling this safely requires a team that can see the whole picture at once and manage several withdrawal processes together, which is exactly how we approach it, rather than treating one drug at a time.

The whole picture, managed by one team
Multiple substances mean multiple withdrawal processes, on different timelines, with different risks. Our physicians manage them together, in one place, instead of one drug at a time.
- A single, coordinated detox plan
- Physicians who manage it all at once
- In-house psychiatry for what drives it
Signs of polysubstance use
Signs include:
- Regularly combining substances
- Using one drug to manage the effects or comedown of another
- Escalating use across multiple substances
- Unpredictable moods or physical states
- Multiple withdrawal patterns when not using
Many people don't think of themselves as "polysubstance"; they just know they're using a few things to get through the day.
Why polysubstance detox requires medical supervision
Mixing substances multiplies risk in two ways. First, overdose risk rises sharply: combining depressants like opioids and benzodiazepines (or either with alcohol) can suppress breathing to fatal levels. Second, withdrawal becomes far more complex: different substances withdraw on different timelines and in different ways, and some (alcohol, benzodiazepines) carry seizure risk. Detoxing from multiple substances at home is genuinely dangerous. Medical detox, with physicians who can manage several withdrawal processes at once, 24/7, is the safe path.
How we treat polysubstance addiction
Physician-Managed Detox
A coordinated plan that addresses each substance safely.
Learn more βResidential Treatment
Therapy and skills in a home-like setting.
Learn more βMedication-Assisted Treatment
Where appropriate for the opioid or alcohol component.
Learn more βDual-Diagnosis Care
Treating the mental health that often drives multi-substance use.
Learn more βContinuing Care
Relapse prevention + personal follow-up.
Learn more βWhen to seek help for polysubstance use
If you're using more than one substance regularly, especially any combination involving alcohol, opioids, or benzodiazepines, the risk of a dangerous interaction is real and rising with fentanyl contamination. This is exactly the situation where medical supervision matters most. A free, confidential call is the safest first step.
Polysubstance use and co-occurring mental health
People who use multiple substances are often self-managing complex, untreated mental health, using one substance for anxiety, another for energy or sleep. Sorting this out requires integrated care that treats the whole person, not one drug at a time. That's our dual-diagnosis approach. This is also why a one-size detox protocol falls short: the plan has to account for how each substance, and the reason behind it, interacts with the others. Our physicians and psychiatry team build that plan together.
Real doctors. On-site. Every day.
Most detox centers run on a rotating staff with a physician who checks in by phone. Regain Hope Detox and Recovery Center is owned and run by two physicians who care for you in person. Here's why that changes everything.
Most centers
- Rotating staff; a doctor checks in remotely
- Orders and changes happen over the phone
- You're one of dozens of clients
Regain Hope Detox and Recovery Center
- Two physicians on-site, in person, every day
- Medication adjusted at the bedside, same day
- A small program where you're known by name
It's 2 a.m. and withdrawal spikes
A physician is on-site to respond and adjust your medication, not a nurse waiting on a callback.
You have diabetes or high blood pressure
A doctor trained in internal & family medicine manages it right alongside your detox.
A medication isn't working for you
The physician who owns the program changes it in person, the same day.
Rated 5.0 on Google
β β β β β 5.0 Β· 15 reviews
βThe Doctors and staff are truly amazing. Dr. Gomez is selfless, compassionate, brilliant, and the perfect person to help you. Absolutely every person who works there is kind, patient, and extremely supportive. The facility is immaculate, and overall it is a safe, comfortable and nurturing environment for healing.β
βThis place was amazing, the staff was great, I highly recommend them, They really care, I know I appreciate what they did for me! You will to, Trust me, if you come here, you want regret it!β
βIts a miracle come true. Almost seems like one of those things you dont seem to belive until you experience it, an I did. Every since day one until the end everyone is so nice an understanding an will work with you do get whatever you need done. I absolutely love it here hate im goin but im sure they have got me to where I need to be physically an mentally.. I've had the best experience that I could have ask for. I really an truly learned so much an seen so much. If you need help here is the place to be I promise you. Thanks docs an the rest of the staff I really do love you guys, just like family I will miss yallβ
βRegain Hope Detox and Recovery Center in Burbank, CA absolutely changed my life.This is exactly what a detox center should be. From the day I arrived until my graduation 40 days later, every moment was filled with love and care that felt like family.The first week was physically rough, but the staff supported me in every way imaginable. When I didn't feel like eating or getting out of bed, Yolanda the house chef brought me homemade chicken soup, fed me, and gently encouraged me. She made me feel truly welcome.The entire team treated me like a person worthy of the very best. Medical care was excellent β vitals, bloodwork, and constant attention to my wellbeing. Dr. Gomez and Dr. Yoo are outstanding doctors with the biggest hearts. They visited often, even on days off, and went above and beyond.For the Fourth of July, Dr. Yoo came in and barbecued ribs, hamburgers, and hot dogs for us. They even made sure we could watch the big fight. Moments like that meant everything.Whether the house was quiet or full, guest comfort and recovery were always the priority. Andy took us on great outings to Hollywood Blvd., Santa Monica Pier, and Venice Beach. Russell led fun walks, and the laughter with the techs (Patricia, Alex, Miguel, Jonathan, and others) was nonstop. Sara helped me with career ideas, and Jackie became a real friend β we spent many nights talking and watching movies.I mention them because each person played a meaningful role in my recovery and made me feel worthwhile.Dr. Gomez took us to tour excellent aftercare and sober living homes. As a MAT center, their medical expertise made detox far more comfortable than I expected. Weekly sessions with counselor Jack and therapist Nora were also very helpful.The facility is beautiful, with comfortable rooms, giant TVs, a nice kitchen, shaded patio with Jacuzzi, a gym with Peloton, games, and scheduled activities like yoga, aerobics, and music lessons.I've been home nearly three weeks and I'm still clean with real hope for the future. The personalized care here overwhelmed me β I was brought to tears multiple times by how much attention was given to each individual.I could honestly write a book about this place. They don't just treat patients β they genuinely love and believe in you.Thank you to the whole team. I love you all!β
βMy experience at Regain Hope Detox and Recovery Center was wonderful! The space is beautiful, inviting and creates the perfect environment for healing. The Doctors are fantastic, and give a highly personalized and caring experience to guests which makes their six person capacity just the right size. The Staff is lovely and the meals are excellent. Highly recommend this center!β
βWhew this is a good one I have waited this long because I wanted this one to be special. Let's start by saying Regain Hope saved my life in ways I never imagined. Not only did they cater to my every needs they event above and beyond to make my detox as comfortable as possible the staff was super friendly they taught me how to prepare for a life of sobriety that matched my energy Dr Gomez was just awesome she made sure to keep us busy doing fun stuff and every time she came she always had a smile on her face and greeted us with love and kindness and that went a long way Carlos thanks for keeping the fridge stocked with milk you did that sir. We went on really nice outings my favorite was the ocean and the LA ZOO. We also had a special guest named Wes that came and taught us about music and even showed us how to salsa and tango and it was a complete blast. The groups helped me find myself in my. Recovery they taught me relapse prevention skills that I'm currently applying to my life today. Please keep Regain hope in mind when looking for a treatment center because they are the best around the house was very organized and I can't forget our chef Patricia love you Patricia your cooking was phenomenal wish I had a chef life you at the sober living I'm at now but I guess the one we have will do for now. I learned one important thing about Regain Hope while I was there and that's I'm not just a number but that I'm Family and they treated me as such and I'll always remember the hard work they did to make me a better version of myself I love you guys and I will be back soon (to visit of course) thank you for helping me get sober.β
βI graduated successfully from Regain Hope on 6/24/26. Honestly, the staff has become a huge part of my recovery. They made it so much easy for me to do the 30 days, Much love to the doctors our dear chef Yolanda and the whole staff. I'm so glad I chose this place. Thank you!β
βRegain Hope Detox and Recovery completely changed my expectations of what treatment could be like. The two doctors are genuinely caring, compassionate, and always go above and beyond to make sure I get the best possible care and health outcome. Their staff are just as incredible. In past detoxes, I often felt treated like a number, but there they truly make you feel valued and cared for as a person. The level of compassion and attention they give is something special.β
βMy experience at this rehab truly changed my life, and there are so many people there I'll never forget because of the kindness, support, and heart they showed me during one of the hardest times in my life. Yolanda, the cook, brought so much comfort and warmth into the place every single day. It wasn't just the food, although it was always amazing π, it was the love and care behind it. She had a way of making people feel at home, even on the roughest days, and those small moments meant everything. Dr. Gomez treated me with genuine compassion and respect from the beginning. I never felt judged or looked down on. She listened, encouraged me, and helped me believe I was capable of getting better even when I doubted myself. That kind of kindness can truly change someone. Carlos made such a huge impact on my recovery journey too. His patience, encouragement, and sense of humor helped me get through some really difficult moments. He knew how to make people laugh when they needed it most and reminded us that healing doesn't mean losing joy. I also really appreciated the owners and how attentive they were to everyone's needs. They didn't make the facility feel cold or clinical. They made it feel like home. You could tell they genuinely cared about the people there and wanted us to feel comfortable, safe, and supported while we healed. One of the things that touched me most was how they handled Christmas. Being away from family during the holidays is incredibly hard, but they went out of their way to make it feel special and comforting for all of us. They created an atmosphere full of warmth, love, laughter, and togetherness that made being away from home a little easier. That kindness meant more than words can really explain. I also want to recognize the entire staff because every single person there played a part in making my experience meaningful. From the techs to the counselors to everyone working behind the scenes, they treated us with patience, understanding, and genuine care. They celebrated our progress, supported us on our hardest days, and never made us feel alone. You could tell this wasn't "just a job" to them. The compassion they showed every day made a lasting impact on me. What I'll always remember most is that this place gave me more than recovery tools. It gave me memories, laughter, and moments of real connection. We had so many fun times together, and in a place where everyone is fighting their own battles, those laughs and shared moments meant more than people probably realize. We supported each other like family. Recovery is hard, messy, emotional work, but the people here helped make it feel possible. I'm deeply grateful for everyone who helped me along the way, and I'll carry those memories and lessons with me for the rest of my life. β€οΈβ
Your insurance may cover treatment
Most PPO plans cover medical detox and residential care. As an out-of-network provider, we verify your benefits free in about 5 minutes, no obligation.
Polysubstance treatment, frequently asked questions
What is polysubstance abuse?
Using more than one drug at the same time or over the same period, for example, alcohol with benzos, or opioids with stimulants.
Why is mixing substances so dangerous?
It sharply raises overdose risk (especially combining depressants) and makes withdrawal more complex and risky.
Can you detox from multiple substances at once?
Yes, under physician supervision, we coordinate a safe plan for each substance involved.
Is medical detox necessary for polysubstance use?
Strongly recommended, multi-substance withdrawal can be dangerous and unpredictable.
Do you use MAT?
Where appropriate for the opioid or alcohol component (e.g., naltrexone/Vivitrol).
Does insurance cover it?
Most PPO plans do. As an out-of-network provider, we verify your benefits for free.
Clinical information on this page is informed by the National Institute on Drug Abuse (NIDA) and the CDC.
The people who care for you
A small, close-knit clinical team, on-site and personally involved in your care.

Mileidys Gomez Gonzalez, MD
Founder, CEO & Addiction Medicine SpecialistFounder, CEO, and Addiction Medicine Specialist at Regain Hope Detox and Recovery Center. With more than 20 years of medical experience, Dr. Gomez leads all clinical care and sees clients in person every day.

Alexis Gomez Gonzalez, MD, MSN, FNP-BC, PMHNP-BC
Psychiatric Mental Health Nurse Practitioner & Family Nurse PractitionerBoard-certified Psychiatric Mental Health Nurse Practitioner and Family Nurse Practitioner with over two decades of experience in psychiatry, addiction medicine, and primary care, caring for the mind and body together.

Nora A. O'Connor, LCSW
Licensed Clinical Social WorkerLicensed Clinical Social Worker with more than 20 years of experience helping clients navigate addiction, trauma, mental health, and life transitions through a warm, trauma-informed approach.

Jack Gould, CADC
Substance Abuse CounselorCertified Alcohol and Drug Counselor with more than a decade of experience, bringing a grounded, compassionate, and creative approach to recovery counseling.
One coordinated plan for the whole picture
Multiple substances need one team that sees all of it. One confidential call, answered 24/7, is the first step.




